تأثیر تمرینات مقاومتی و هوازی با شدت‌های مختلف بر بیان ژن BDNF و گیرندۀ TrkB در موش‌های اوارکتومی‌شده

Introduction: This study aimed to investigate the effect of resistance and aerobic exercises with different intensities on BDNF & TrkB receptor gene expression in ovariectomized mice. Methods: Sixty 6 to 8-month old mice with average weight of 230 ±10 g were randomly divided into six 10-member groups: ovariectomized + high-intensity resistance exercises, ovariectomized + low-intensity resistance exercises, ovariectomized + high-intensity swimming exercises, ovariectomized + low-intensity swimming exercises, control and sham. The animals in the exercise groups performed low- and high-intensity exercises for 8 weeks, one session a day, 3 days a week.  After the training protocol, the animals' hippocampus tissues were removed. Quantitative Real-time RT-PCR was used to determine the changes occurred in BDNF and TrkB gene expression. The data were analyzed by SPSS 23 using ANOVA at the significant level of α = 0.05. Results: BDNF gene expression significantly increased in the high-intensity resistance exercise group (P<0.036), but the difference was not significant in the low-intensity resistance exercise (P<0.975), high-intensity swimming exercise (P<0.141) and low-intensity swimming groups (P = 0.998) compared to the control group. TrkB receptor gene expression increased in the high-intensity resistance exercise (P<0.036) and swimming exercise groups (P<0.002), but the difference was not significant in the low-intensity resistance exercise (P<0.442) and swimming exercise groups (P<0.688). Conclusion: High-intensity swimming exercise increased BDNF and TrkB receptor gene expression. However, high-intensity resistance exercise is likely to offer better results.